I recently bought and watched "Sam and Max: Freelance Police", the animated series on DVD. I always loved Steve Purcell's comic by that name, and was intrigued with how they might translate some of his zanyness to the small screen. TO my pleasure, they did an okay job. Watching it with my ten year old daughter, it was cool to see that the occasional gag/story/personality trait that they left in from Purcell's comics were the very things she laughed at the hardest. WHY some of the backgrounds are done in a completely different style than the characters, I will never understand. And even though I'm sure they added the little girl computer whiz for kids to relate to, I found her a needless addition. I mean, come on, you've got a dog and a bunny-thing... kids love animals, so why do you need the girl? Those criticisms aside, I think the show is a pretty decent intro for kids into the world of these great characters.
But if you want REAL Sam and Max, then track down the comics!